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1,3,5-Trimethoxybenzene and Aromatic Compounds

2024-08-29

Aromaticity of 1,3,5-Trimethoxybenzene


Definition: 1,3,5-Trimethoxybenzene is an organic compound containing a benzene ring in its molecular structure that confers it with aromatic characteristics. Aromaticity is a fundamental concept in organic chemistry often associated with benzene rings and their derivatives due to their unique stability, reactivity, and spectral properties. 

Structure: The molecular formula of 1,3,5-Trimethoxybenzene is C9H12O3; the simplified structural formula is C6H3(OCH3)3. This indicates that methoxy (OCH3) groups replace the hydrogen atoms at positions 1-2-4 on the benzene ring. These substituents not only preserve the aromatic nature of the benzene ring but also impart new properties and potential applications to the compound.


Properties of 1,3,5-Trimethoxybenzene as an aromatic compound


Physical properties: It exists as white crystals with a low melting point and moderate boiling point which are closely linked to its molecular structure and aromaticity. 

Chemical properties: Due to its inclusion of benzene rings and methoxy substituents; it exhibits notable chemical stability while being capable of participating in various organic reactions such as substitution reactions or addition reactions.

Solubility: It's insoluble in water but soluble in organic solvents like methanol. This solubility can be attributed to its molecular structure and aromaticity.


Utilization of 1,3,5-Trimethoxybenzene across various sectors


Pharmaceutical industry: As a crucial intermediate compound in pharmaceuticals and organic synthesis processes, 1,3,5-Trimethoxybenzene can effectively facilitate the production of diverse bioactive substances, such as Buflomedil hydrochloride CAS: 35543-24-9, a novel vasodilator for peripheral vascular ailments.

Fragrance & flavor sector: Owing to its distinctively aromatic scent, 1,3,5-Trimethoxybenzene routinely serves as either primary material or key ingredient fragrance formulations.

Other industries: Furthermore, this compound finds utility within industrial domains like pesticides and dye manufacturing—functioning either as raw material or auxiliary component for synthesizing other compounds.


The molecular structure of 1,3,5-Trimethoxybenzene contains benzene ring and methoxy substituents, which gives it unique physical and chemical properties, and makes it have a wide range of application prospects in medicine, spices, pesticides and other fields. At the same time, as a member of the aromatic compounds, 1,3,5-Trimethoxybenzene also shows the important position of aromatic compounds in organic chemistry and practical applications.


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